There are absolute limits to what kind of resolution you can extract from the scanner.
No amount of fiddling with holders, Newton ring free glass or liquids is going to change that.
Also there are limits in the negative: One thing are lab tests with flat targets with a tripod and another thing is real photography.
In real photography:
> the scene is usually in the DOF and not in the perfect plane of focus, so most has some defocus,
> Many often use a wide aperture for selective focus and the lens is not in peak performance, or sometimes we close a lot for DOF having some diffraction
> handheld shots always have some shake
> textures have no 1000:1 microcontrast, so film does not deliver 150lp/mm but 40lp/mm
So most of the shots are very easy to scan because basic scanners are outresolving what real shots have, there are some excetionally sharp shots that may deserve a drum scan, for sure, but not many, say 1/30.
Anyway, considering cost, it's always cheaper to shot a larger format than paying for an expensive scanning, a drum scan of a 35mm frame may cost $20 to $50, while a MF shot is less than $1, and that MF shot scanned with any decent consumer scanner will be many times better than the drum scanned 35mm shot.
The same happens in LF, if 4x5" has not quality enough for you in the epson then shot 5x7 ! you may have to split 8x10" sheets, but today four 4x5 drum scans pay for the IR googles allowing a convenient splitting.
No doubt that a drum is a way superior machine, the question is when it makes sense or not.
Going back a bit to this thread, it would be interesting to see what evolution film would have had for better scanning.
For the same film speed there is a balance between cloud size and and cloud overlaping, to not generate color noise in the scanning, a color is often mapped in the three color layers, so how clouds overlap may concern noise in the discretization.
perhaps color film could have been re-engineered to increase resolving power from smaller clouds while ensuring a good overlaping. My guess is that if money had been there for R+D then this would have been a field for improcements.