The discussion has partly moved into a pixel peeping territory. Fully agree resolution isn't everything and 32x40 inch print is plain huge and out of consideration for majority. Ultimately isn't this more about what is the particular subject matter we shoot rather than even the final print size? Subject may kill some negative sizes due to shear gear size needed, or it may require best possible detail rendition which may force cumbersome gear to be used regardless of its challenges for a particular case.
If we agree that the larger the negative the easier it is to print, no matter the print size, then subject / gear considerations may just as well be the determining factor. I still am in a camp where 645 is just about as universal as it can get for all above to be covered in most cases and deliver high quality final image.
Looking at my own gear: I love how RB67 works in spite of its brute size and weight, it affords complete system flexibility yet it is not for everyday lunch, Fujica 690 gives a huge negative, dumps the need to think of a what lens to take out, yet still is large and not light either. Then I go down to Pentax 645 with its basic compactness, fast operation and still delivering a rather large negative. A 6x6 TLR makes all before it go away when light and cute is called for, but brings on challenges for some subjects and as everything else, isn't a go to on any given day. What does work in the end is a pleasure of using reliable gear even if the day did not bring the results one had hoped for. I know this is not what those making a living from photography are often concerned with. Just saying, negative size to use has more to consider than densitometric results.