Size only matters with respect to viewing distance. Billboards can be printed at 20 dpi. Make an enlargement the size of a billboard, it'll look great from 1/4 mile away.
I've made 16x20 enlargements from fine-grained film that withstand close scrutiny. But I've made 8x10 enlargements from grainy film than look like they're printed with Elmer's glue and sand. But, you know, sometimes you feel like nut, sometimes you don't.
I could probably make a larger, cleaner enlargement from a 4x5 negative made of an 8x10 print from a 35mm negative - and I'd have the advantage of being able to do all the dodging and burning while making the 8x10. Or touch it up with a pencil or ink. Or draw moustaches on faces.
I've made 16x20 enlargements from fine-grained film that withstand close scrutiny. But I've made 8x10 enlargements from grainy film than look like they're printed with Elmer's glue and sand. But, you know, sometimes you feel like nut, sometimes you don't.
I could probably make a larger, cleaner enlargement from a 4x5 negative made of an 8x10 print from a 35mm negative - and I'd have the advantage of being able to do all the dodging and burning while making the 8x10. Or touch it up with a pencil or ink. Or draw moustaches on faces.