From the tests I have done, there is quite a difference between a scan and a print, although it doesn't really show up until you print larger. Scanners do not image the grain in spite of what everyone blathers on about on the interwebs. I chuckle when people say that
their Epson scans the grain. Ain't even close.
Here is an image of a scan from a Nikon 4000 at 4000 dpi compared to a scan of a print matched for size. You can clearly see the difference. Of course this would be something like a 26 or so inch print, but you can clearly see how a darkroom print done right looks like. I think this is a 400 speed film IIRC, so something with less grain would be even more dramatic I think.
Again though, it just depends how big you are going to go whether or not you will actually
see a difference. I can't really talk about color prints, although I've seen some extraordinary Cibachromes and I haven't seen a digital print that was the same. I couldn't qualify why though since I am not experienced with color printing in the darkroom and it has been a while. I suppose it would be similar to black and white. If you ever get the chance, look at a Christopher Burkett print.
Here is the comparison image. Neither side is sharpened or manipulated. If you download this image and shrink it in Photoshop you will see that at a certain point it won't matter-
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