Adapted lenses can work well, especially since most of what is considered medium format for digital is quite a bit smaller than medium format film frame sizes so you are using the sharpest part of the lens.
Not only this but also for tilt-shift photography.
However, in my experience using an adapter ends up adding weight and bulk to an already cumbersome set-up, best used on a tripod in most cases.
I was planning to buy the widest native lens, the 23mm, for my Fuji GFX. However, I changed my mind after participating in the blind test of wide-angle lenses. The images were shown without the individual lens profiles applied. The awful chromatic aberrations at the edges of the 23mm lens reminded me of typical wide lenses from the '80s.
Furthermore, I have also seen the zoom lens 32-64mm without its lens profile applied: the barrel distortion made this lens looks quite cheap.
The GF 110 is the only one worth buying, but I already have the amazing Planar 110/2, which, when used with the adapter, is as big as a GF lens.
Older medium-format backs don't do high ISOs very well, limiting the use of higher shutter speeds for sharp hand-held shots. Modern IBIS and high-ISO digital MF cameras can overcome that if you are willing to spend the money. But then, why not go all the way and use dedicated lenses instead of repurposing old film lenses unless you are going for a certain look?
If we're talking about top-notch professional medium format lenses, there are no old film lenses. They produce pretty good images, even though they lack individual lens profiles.
For my taste the GF lenses generally produce quite disturbing bokeh, whereas medium format lenses (Pentacon Six, Kiev, Hasselblad, and Mamiya 67) produce a very natural and pleasant falloff. One might call it "a certain look."
For me, the exception to all that is a Hasselblad film body and lens with Hasselblad's digital back or the elusive Rolleiflex/Sinar/Leaf Hy6 or Contax 645 with a digital back. Those bodies don't need adapters to use MF film lenses and can produce wonderful images. Still heavy and bulky, though.
It's very subjective. For instance, the Mamiya 67 and the Pentax 67 feel heavy and bulky to me, but the Kiev-88, my first medium-format camera, feels quite compact and handy.
By the way, the Hasselblad 907x is the first digital back that can be used with a Kiev-88 without limitations. However, the back needs to be modified slightly.