Are you running the latest version of Epsonscan? There should be a check mark. See photo of page from the Epson manual. You can get software and manuals and drivers from Epson site.
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FYI, here is what I have learned about running Epson software with my Mac.
1) My issues were not unique. There have been problems with the software running on a Mac for years.
2) I ran the patch that someone suggested (Epson Scan Common Updater v1.00 from their website) and my operating issues were solved
3) I realize the scanner ran fine but the digital ICE feature was no longer available
4) I contacted Epson support via email from their website and they advised that ICE is not available after running the patch.
5) They sent me a link to download free Silverfast software which provides a ICE like feature. Here was their response about ICE:
"Thank you for your response.
Please be informed that this updated Epson Scan version does not include Digital ICE. As a solution, we are providing the SilverFast SE Scanner Software free of charge. This software includes iSRD®, an Infrared Dust and Scratch Removal tool that you can use in lieu of Digital ICE."
6) I have downloaded the SilverFast software but need to learn how to use it. It does not look anything like the Epson software so I have to get through the learning curve if I want to scan with iSRD to fix scratches, dust etc.
Being a casual scanner for uploading photos and slides for internet viewing, I doubt I will go through all the effort to learn how to use it properly.