I can't comment on giant blow-ups as I can't afford to make monster prints, nor do I have the space or interest for monster prints. The biggest I've worked with is 13 x 19. But majority of my work is 11 x 14.
But it just depends on the neg or chrome when it comes to wet vs digital. When it comes to sharpness, it all depends on the scan.
Here are 2 examples of wet vs digital. One with a terrible neg, one with a good neg.
Above: Vintage wet print left, digital print with 2.5 hours of L.R. right. Only light in the room was the window.
I made the wet print when I was a teen in the 1970's. If I made it now I probably could do better, but I could do nothing close to the digital version. You can't translate 2.5 hours of L.R. to the 20 second exposure of the wet darkroom. Sure you can add masks, but it all degrades the image.
Above: Vintage 1972 Agfa Brovira left, inkjet 2012 right.
Inkjets have their downfall. They are susceptible to solvents ruining them. They have good water resistance when cured. They are not as good with water as silver prints, but are about 85% to 90% as good with water. (generally speaking when we are talking about just soaking inkjet prints in water.)
Above: Day 5 of water submersion tests of inkjet prints.
RC inkjet do better in water than fine art inkjet, but the fine art inkjet still does remarkably well once cured.
Above: 1 year sun test of Epson pigment inkjet print with gloss optimizer. The gloss optimizer extends to the marks on the side of the photo. 'S' = sun for 1 year. 'D' = dark storage.
Above: Selection from The Americans…60 years after Frank
Pigment inkjets are pretty light fast, but will start to fade in the sun a little after 1 to 1-1/2 years, but just sightly. After 2 years + the fading gets worse. Dye transfer prints will fade in the sun very quick, within a few months very badly. Dye transfer prints have very poor water resistance and will start to lose noticeable dye within 30 minutes of water submersion.
Above: Eastman Kodak dye transfer fade test from 6 months of sun. 'S' = sun for 6 months 'D' = dark storage
Fuji 'C' prints are not as good as pigment inkjet prints for fading, but are about 85% to 90% as good. Fuji 'C' can be considered as pretty archival as long as not displayed in light all the time and generally on par with lower level pigment inkjet prints. Metal prints are about 75% - 80% as good as inkjet for fading. The top Cibachrome material was excellent for fade resistance. A dye transfer print should never be displayed long term. Just take it out to look at it and display a copy of it. Dye transfer prints will fade in normal room light.
Inkjet prints problems with fine art papers is the fragility. They will mar up if you run a fingernail over them, the watercolor papers will flake off if handled rough. The matte BW inkjets can mar up very bad if handled. You got to sleeve or glass em quick. Even with sleeving they can mar up just from trying to get in the sleeve and from running through the printer. The amount of retouching and post processing you can do with inkjet / digital is extensive. No so with wet prints...even with 10 Ansel Adams on the job.
Printers, paper and ink matter a lot with inkjets.
Left: Printed with Epson R2000 on matte paper with matte black ink.
Middle: Printed with Epson R2000 on semi-gloss paper with gloss black ink and gloss optimizer.
Right: Printed with Epson 3880 with the same semi-gloss paper as the middle sample using gloss black ink. The Epson 3880 printer uses 3 separate ink cartridges of gradients of black ink. Whereas the Epson R2000 uses one black ink. (Gloss or Matte)
The Lost Princess (Candid)