The short answer, no, there isn't that much difference.
There are many other things to consider that may drive your decision for, or against the APO lenses.
If you routinely enlarge past 11X14 or 16X20, maybe then the APO would be a better choice.
There are about 13 different focal length lenses available for the RZ, plus a zoom and a fisheye.
A 1.4 tele-converter, too.
What percentage of your shooting will involve using the 250mm focal length?
How many other lenses/focal lengths do you have?
There are only two lenses, out of the 15, with focal lengths longer then the 250mm.
They are the 350/360mm and the 500mm.
At this point, given that you state the RZ is new to you, I might suggest that your money would be better spent adding some of the other lenses to your kit first. Big bang for the buck, is the 180mm.
Which lens are you currently using as your standard lens? The 90mm, 110mm, or the 127mm?
If I don't need the added speed of the 110mm, I have always preferred the look of my 90mm as a standard lens.
Do you have any of the wides? Those are the 50mm, 65mm, or 75mm, (and the 37mm fisheye).
Don't completely dismiss using a tele-converter. For me, it was my third lens, which gave me a total of four focal lengths, when combined with my other two lenses I had at the time, the 110mm, and the 180mm.
The 1.4 converter only slows you down by about one f:stop of light.
I don't know your budget, but APO's can run well over double their non-APO counterparts.
Most lenses for medium format are great lenses; the format demands this.
You have to ask yourself, for just a [little] improvement, is it worth double your money per focal length,
or would you rather have twice the number of lenses/focal lengths?