John, I think so. But in your case, what you want is for the film AND paper together to be fairly straight-line reproduction. You might want to think about the choice of paper from this viewpoint as well.
I don't know if he's here, but DK Thompson does (or at lead had done at one point) this kind of work for his main work. He might be able to tell you how he does it. Ken Sinclair is another person you might want to ask.
I agree that 100-speed tabular grain films are easier to use and deliver just as good results, if not better, in many applications. Extreme accutance developers may be an exception, but such a developer is not my preferred choice for making enlarged prints.
In terms of grain, I have made virtually grainless 24 inch prints from 35mm Acros using my new developer. I used a fixed-focal length lens at f/5.6 with the camera on tripod, but the lens's resolution was the limiting factor rather than bothering grain. I'm not sure if there is anything to be gained by using Pan F Plus or APX25, or KB14 for that matter.