Yes, wear gloves. It's poison. But if you are developing sheet film in trays, that's easier said than done. In fact, the first time I tried it, the films just slipped and slided and I coudn't get a grip on them so I had to take off the gloves and get my hands in the Pyro. But that's not a good idea. Since then, when I develop sheet film in Pyro, I do it in dip & dunk tanks. Also, from my experience, you can simply ignore Gordon Hutching's advice to never develop sheet film with Pyro in tanks. I have never experienced the problems he mentions. In addition to that, you can also ignore his advice for developing sheet film (with pyro) in trays that you should have the sheets emulsion side down. Not only does that advice not make logical sense, but it simply did not prove to be accurate in my own testing. But I suppose his advice might be based on the particular way he agitates his sheets.