They don't seem to constrain lens design options for Hasselblad.
They do, because shutters cannot be "grown" to bigger sizes so easily. So the shutter throat diameter limits the max speed of the lenses.
The same happens in the RB67, and for example you see the normal lens (90mm) being f3.8 (3.5 in a later model), and the 180mm lens being f4.5. However, if you would want a theoretical 180mm f2.8 lens for 6x7 format, it would be so big and heavy that it would render the lens impractical.
The Pentax 6x7 machine has a focal plane shutter and it has a much faster normal lens available. However, if forums are to believed, the 6x7 has some residual vibration that limits its use on slower shutter speeds, while the Mamiya RB is steady as a rock and can be used down to 1/30 and 1/15 handheld (if you have good technique.)
Now, i'm perfectly happy with the RB lenses, to be honest, and I haven't heard any Hasselblad or Mamiya user complain of having a slow 1/500 (or 1/400) speed, or complaining about the lenses' speed. Depth of field in Medium Format is extremely narrow at those apertures!
Overall, i prefer central shutters due to less vibration compared to a normal focal plane shutter. And, in the case of the RBs, Hasselblad and similar shutter-in-lens camera, there is a big reliability advantage: one of the fragilest camera parts (the shutter) is removed from the camera. Thus, if you have shutter failure you just change the lens and keep going.
Another advantage of central shutters, often unnoticed, is ergonomics: Most cameras with in-lens shutters have the shutter speed ring and the aperture ring next to each other. In the case of the Mamiya RB and C, it allows you easily to see the available speed+aperture combinations for a given EV value at a glance (i.e. 250+f5.6, 125+f8, 60+f11, 30+f16...)