A 150mm f/5.6 lens - for example - isn't exactly bright when you are composing and focusing. And if your negative is dense, and you want to use f/5.6 to keep the exposure time reasonable, using it wide open may not be optimal.
But it certainly would be usable
There maybe a slight drop in contrast compared to an 80mm. This is due to the longer exposures required, and the paper's reciprocity failure.
Some years ago I was given two turrets full of Compmponon (& S) enlarger lenses by my local pro lab, who had switched from roll-head printers to a mini-lab. Each turret contained 50mm, 80mm, 105mm & 135mm lenses, used for 35mm & 120 negatives. The degree of enlargement was determined by the focal length chosen.
Terry had worked for Pavelle/Durst UK as a technician and explained that each turret was set up and the lens apertures locked with a grub screw so all the lenses gave exactly the same exposure time, this ensured consistent contrast and colour balance regardless of the print size. You see the same change in contrast with B&W papers
Echoing Matt's points a 10"x8" print off a 6x6 negative with a 150mm is equivalent to a 20"x16" print (approx) off a 5"x4" negative with the same lens. It's making it all a bit harder,
Ian