I don't think of f-stops in terms of comfortability. In other words, I don't usually shoot, or not shoot, at any particular f-stop. Sure, sharpness is important. But it's only one part of the puzzle. Depth of field is also important. So is shutter speed, which can effect my f-stop choice indirectly. I choose my f-stop based on how I want to balance those aspects. I only prioritize sharpness if it's important to the photograph I have in mind. Sharpness is often overrated. But sometimes it's the most important attribute.
Having said all of that, I rarely shoot 35mm film at f22. Then again, I rarely shoot 35mm film for landscapes due to the low level of detail, which is usually important in 35mm. With 35mm digital, I can usually shoot at a lower f-stop and image stack and when I do need a smaller aperture, I can always sharpen in software. With large format, I frequently shoot f22 or higher.
Basically, the rules of photography tell me what to expect, not what to do.