In Photoshop I immediately convert to 16 bit and then de-saturate to grey
OK, so you only do B&W?
Why do you compress everything into 8 bit initially (scan to jpeg) and then go back to 16 bit instead of scanning in 16 bit natively? The latter really *is* better if more dramatic contrast adjustments (possibly local) are done at a later stage as you'll avoid posterization. Notorious are posterization artifacts in bright skies when working with negative scans.
Yeah; agreed, it doesn't come close. In fact, I've never found any significant benefit in scanning at more than 2400dpi on the 4990 (I've had one since it just came out, so approx. 20 years). I've done the res-tests scanning at various resolutions and then downsampling, critically assessing the resulting images to see if any additional real detail is captured above 2400dpi, which I've never found to be the case (nor have other people who have systematically tested these scanners). More pixels does not result in more resolving power. It does significantly affect productivity and storage requirements.Now I am not claiming that the resolution of the images for the 4990 is 3200 dpi ( 62 lp/mm)
I'm with you on the issue of disabling most enhancements etc. in Epson scan. However, for optimal color fidelity and the most flexibility in B&W edits, 16 resp. 48 bit scanning is absolutely essential; JPG doesn't cut it. JPG/8 bit is fine for B&W work where not much adjustment is foreseen and for color slides under the same conditions.
For amusements' sake, here's 3 scans of the same negative made with 3 scanners, all downsampled to the 3200dpi native resolution of the lowest common denominator (so not the 4990):
No sharpening was applied to any of these scans. They were acquired, 2 out of 3 were downsampled to 3200dpi and pasted here.
Image courtesy of @Don_ih