... the apparent grain gets much smaller scanning at 4800 dpi, and can be sharpened a lot more.
A good point. A film archivist I know and have great respect for (having seen his finished work) once gave me the following advice on scanning which he applied to both 35mm and roll films for a university library archive. I have to say his results certainly spoke for themselves.
1. Use the professional mode but turn off everything on the scanner. especially sharpening. Go for a basic scan. This will (usually) be quite gray.
2. Scan to TIFF.
3. Set 120 at 3600 and 35mm at 4800.
4. Reduce your scan to a sensible size for storage.
5. Never do any work on your original scan.
6. Number your scans, keep a notebook with detailed notes.
7. Be ultra selective. Don't scan every image in your negative files. Life is too short!
I have followed this advice and produced some excellent scans, but have never put any of these points to any in-depth testing.
Anyway, FYI. I am particularly interested in others' comments on points 2, 3 and 4.