I think my screen is high DPI I don't know if that matters?
Screen resolution is driven by how many "dots" per inch the screen has, end of story.
Most monitors have 72 or 96 dpi. HD TV and the like are changing that and I'm not an expert there but most people are not using their HD TVs as their computer monitors. Even if your machine is at 96 dpi the viewing dimensions you are seeing on screen are way bigger than any print I've ever heard you talk about doing and the true resolution is nowhere near that of a print.
There are real uses in the digital world for viewing and manipulating certain things at 1:1 magnification, but it isn't about seeing a facsimile of the finished print at the right size, it is simply a useful technical tool akin to using a loupe to view a print. That is not how our "audience" (other than technophiles) will ever view our prints.
Enough with the digital lesson.
My point in doing that math is to illustrate that enlarging a 4x5 negative to 30x(ish) times larger than the original isn't necessarily a good indicator about the acceptability of it's look printed at 4x (20"), 6X (30"), 8X (40"), or 10x (50").
The entire look of the print changes with each change in print size, just like it changes when we switch film formats but retain a given print size.
The look, the tonality, the detail our eyes can resolve, the "perceived" sharpness, and all that jazz changes with each change in magnification. The "look" of a photo isn't a constant unless you fix all the variables.
The acceptability of changes to magnification is highly dependent upon: the important subject matter in the scene, the size of the subject matter in the scene, the mood we want to portray, the lighting, the lens you choose, the clarity of the air (haze, dust, moisture), the cleanliness of your lenses, the use of a lens hood, wind, and all the other normal blah, blah, blahs you can think of.
Yes, the effects you are seeing are real and visible at 33x, but are they discernible or even important in a given print?
You can't answer that until you put each variation on paper, full size, at least once for each subject type. Printing a small section to 8x10 paper isn't gonna give you the whole story, if you want to see how the picture "works" at 40x50 you gotta a print at 40x50 and put it in the house where you'd like to hang it (like over the sofa) and under the lighting you want, or that's there. Once you get to that point and you are standing across the sofa from the print then you'll be able to judge if you prefer the tonality of DD-X over the sharpness of FX-39 or rotation vs hand agitation or ...
There will be a difference, which you prefer may surprise you.