E100G has more natural skintones than E100VS. However, if you want really saturated yellows or reds, then E100VS is a great choice. E100G is slightly less contrasty than E100VS.
In Fuji films, Astia 100F is a good comparison to Kodak E100G. In general, the dark greens response is better in E100G, medium green tone response is better in Astia 100F, and lighter greens are about equal. Contrast, grain, and scanning performance are quite close. I tend to prefer skintones on Astia 100F over what 100G renders, but the difference is subtle.
The advantage of colour transparency is that you can directly view the colours, and compare that to any final prints made. I often see comments about greater latitude in colour negative film, but that should never imply that it is difficult to get nice results from transparency film. You can be further off on your exposure with colour negative, so if you are less sure about your equipment accuracy, or don't ever want to bracket an exposure, then just use colour negative. If you have a reasonably accurate light meter, and your shutters on your 4x5 are fairly close to accurate, then you will have few issues with using transparency film.
Scanning is something better left to other forums. You will find few answers on APUG. I suggest posting your same question to the Large Format Photography Forum:
http://www.largeformatphotography.info/forum/index.php
You will find more answers there, especially since the kind of scanner and scanning software you use make a huge difference in results, sometimes more difference than your choice of film. Nearly all newer films scan quite well on good gear run with good software by an experienced scanner operator.
Ciao!
Gordon Moat