The thing about the mirror space is that it creates asymmetry in the design.
Asymmetry in the stop position and in the power balance from front to back.
With primes, the problems already start at 50mm focal length.
A 50mm f/2, or 50 f/1.8 is a fairly small unit and the 38mm back focus is a reasonable fraction of the 50mm, so an SLR lens of this spec is almost the same as an RF design, and they both achieve excellent performance both at full aperture and in the field when stopped down.
However at 50mm f/1.4, this is an inherently more bulky lens because of the aperture and the number of elements ( 7 ) required. Even using very high-index glass, as they do, the natural back focus of a lens like this designed without constraint would be 35mm or less. So, you have to 'force' the design a little to achieve the mirror space.
So instead of the front group and the rear group having roughly the same power, the front group now has to be a little longer in FL and the rear group shorter.
The stop moves back a few mm within the lens form - which enlarges the front element slightly.
The asymmetry in the powers makes it harder to correct distortion to zero, and lateral colour in the field.
The trade-offs are not too severe though, both and RF 50/1.4 and and SLR 50/1.4 can be very good, but close inspection of the two designs and their performance measures, will show that the SLR lens typically has 1.5 to 2% barrel distortion whereas the RF lens will be close to zero.
The MTF in the field, particularly when stopped down, will be slightly inferior towards the corner, in the SLR lens.
This can all be confirmed by looking at the MTF and distortion of a Leica R 50/1.4 and a Summilux-M 50/1.4
For very wide angles, the design differences can be very obvious.
A 19mm lens has to have a back-focus distance of twice its focal length in order to work with an SLR.
This can only be achieved by using huge amounts of negative power up-front, with a much more positive group in the rear.
Given the strongly diverging field angles of the corner bundles, this makes the front group pretty large.