My takeaway as one still in learning mode is Ralph W. Lambrecht a couple pages back has the right bottom line on the subject. In addition the developer/dilution choice has some bearing on whether the ISO is achievable. The film cutsheet shows what the film speeds go with what developer/dilution. Massive development chart also has good info, to decide what to set for EI on meter. It was my takeaway from a thread started only a few days ago (placing shadows on zone iv) on the same subject, where summarizing Michael Barendt and Bill Burk's comments come down to understanding what contrast level you are aiming for, and good understanding of what you are metering to get the shadow detail you are looking for. Those guys have it together, and have development charts for contrast index (CI) to prove it. Their final prints speak to their excellence. And Ralph W. Lambrecht wrote the book... And to couple this discussion with a thread started just today, one film one developer, I use only use HP5 for 8x10 because of the speed and the desire to shoot much smaller f/ and I use FP4 in the 4x5, the only films I develop. I settled on using Perceptol as my default personal choice for most developing, if I am able to use a liter of stock up as a single shot in BTZS tubes. If I only have a few sheets to develop and I don't have a compelling reason to use perceptol, I will use DDX, for reasons I don't know other than it is easy to work with for me and my lab conditions. Point is, I will be preparing the development curves for HP5 and FP4 developed with perceptol diluted 1:2 using my development process, temp, as my default. For developing in DDX, if I feel that the negative will be produced that I desire, I will just guestimate from the DDX and film cutsheets. Again my many thanks to Bill, Michael, Ralph and many others who chime in and help us who come to APUG for this very reason - their time is theirs not ours and they are contributing greatly to so many more with their time. There have been at least 4 threads in the past week on these related topics that they all have helped out on.