Tony
having played with various scanner softwares since 1999 I feel that none are intuitive, if you happen to get the hang of one over another then go with that! I have struggled with vuescan since version 7.1.someting and just never got to like it. The same is not true of the Epson software which I have been gradually finding sophisticated control within the simplicity of presentation. For instance somone asked me once about doing bulk scanning on the Epson, and thought it was impossible. I wrote
this page to explain that to them.
Your mileage may vary (as always) but I like the Epson scan the most for what I do.
To answer your question on noise I would ask for some information. Are you scanning as black and white or are you scanning as colour?
For instance using the Epson (or Nikonview) software and adjusting the controls for each channel rather than allowing the software to do what it wants with what it thinks your negative looks like is often better. I've explained that in
this article.
I find that there is some focus issues and differing channel noise between R G and B layers, and so for black and white I use professional, scan everything as positive and then invert, and use only black and white setting for my scan. This optimises my scans considerably. For example if you read
this page, you can see how I've found that each layer has differing focus issues. If you examine your own scanner output perhaps you can see if this is applicable to you. If so then you can try my advices there.
Essentially when combining differeing noise levels (present in each of the R G and B you compound the noise that may be present.
Epson's sharpening is not as controlable as an unsharp mask in photoshop, so you may find it better to start with your sharpening there.
Also, before applying curves (after inverting and level settings) on your scans consider using unsharp mask at a radius of 60pixels and 14 ~ 20% to boost your contrast and then applying your curves to taste. .
see if that helps your scanning?