Dust reduction does result in a slight softening. Unfortunately, the vast majority of negs I'm scanning are decades and decades old and time has not been their friend. Lots of dust stuck in the emulsion, scratches, bits of loose/missing emulsion, etc. Included are the negs of my wedding back in 1973. No photos exist anywhere -- just the negatives -- so I can't take a chance on trying any rewashing methods. So far, the OpticFilm 120 seems pretty good. Medium format negs scan much sharper than they do on my Epson V850 and I can't detect any differences on 35mm between the Plustek and my Coolscan 5000. Now that the Plustek has proven itself, I'm going to try cleaning the mirror on my Coolscan.