I use a Black Rapid, but any other brand of similar design is probably just as good. Wasn't sure if I'd like it at first, but now I'd never go back to a traditional style strap, as they always seemed to get in the way due to their placement high up on the camera body.
I was initially concerned about the camera hanging upside down by only the tripod socket. If you think about it, the socket is screwed into the main frame and then covered by a bottom plate/cover, which is itself then screwed into the frame (at least on my Nikons).
Granted, I wouldn't use a ginormous lens unless it had a collar, but then the strap connects to the lens collar, not the camera.
If you want extra security, you can use an additional small tether (or a length of para-cord, or whatever) from the carabiner-style connector to the regular strap lug. Make it short so it stays close to the camera body and doesn't get in the way. Black Rapid sells these as extras, but I don't use one.