It's pretty easily portable if you have only one body and one lens or maybe two. You can carry three lenses and several backs and a second body easily if you have a good backpack for it. It also helps a LOT using the WLF instead of the prism. I don't understand the comments that always come up about the size and weight of these cameras making them unluggable. I find them to be much easier to handle than a P67, personally, and much more useful in "the field."
My standard RZ kit when I go traveling is a combo of my kit and my friend's. It consists of:
2 RZ bodies
7 backs
65mm f/4
110mm f/2.8
210mm APO
WLF
Prism
two rubber lens hoods
bellows lens hood
It all fits into a medium-sized backpack. The tripod (Bogen 3036 or 3051) goes across my chest or over my shoulder on a strap. You start to feel it after maybe a mile, but I have pretty easily covered 8 miles of hiking this way in about a 6 hour period. (Going slow, taking lots of water/picture breaks is the key.) For more intense hiking (meaning overnight camping, really), I take one body and two lenses only, usually three backs, and no prism.
For anything but the hiking/camping I mentioned, I feel no need whatsoever to ever pare down the kit for travel.
For simple, quick, day to day use, I'd probably just have a body, WLF, two backs, and two lenses (65 and 110). This is a very manageable setup with a smallish bag.