How far off the mix is when you use a partial package of premix depends very strongly on how well the components were mixed in the first place, and what influences might have caused the components to stratify in the package after it was sealed.
Different particle sizes of the same density will tend to sort with the larger particles on top (this is a known geological phenomenon, whereby frost action produces patches of soil with boulders on top, gravel and then sand below). Particles the same size but different density will tend to sort with the least dense on top, assuming the difference is more than few percent. Both of these processes will take both time and movement of the package contents.
How much that affects your end product will vary. If it works for you, go for it. I find liquids keep well enough in well sealed PET that there's no harm in mixing a whole 5L Xtol or similar, even though that's more than a year's supply.