Phenidone substitute

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archer

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Is there any reason that Dimezone S should not be substituted for Phenidone in formulas that call for Phenidone and are the two chemicals substituted equally weight for weight?
Denise Libby
 

Gerald C Koch

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Phenidone hydrolyses in alkaline solution. The higher the pH the greater the rate of hydrolysis. For Dimezone and Dimezone S the rate of hydrolysis is slower. Since the molecular weight of each is larger than that of phenidone more must be used to get the same activity. I have read one claim that says that the activity of the Dimezones are less than that for phenidone even when compensation is made for the differing MW's.
 
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