And still, dry plates and early cellulose nitrate film were a big improvement over handling ether-based collodion by the open flame of candle light or oil lamp, as was the case in the 1860s. It amazed me that anyone using collodion wet plates or tintype in that era before any kind of electric light managed not to burn their darkroom down (a fire that would be very, very quick, likely inescapable). Not to mention the tendency for ether to form crystals of an explosive peroxide around the stopper in storage (this has been the cause for evacuation and bomb squad calls in numerous high school chemistry labs over the latter half of the 20th century) -- friction-sensitive explosive that can detonate from trying to open the ether can.
With modern materials, you can work in a darkroom for years and never handle anything more hazardous than rapid fixer (don't drink it, keep it out of your eyes, but otherwise pretty tame stuff). Now, if you like archival toning or the tonal change produced, you have to deal with selenium toner -- but that's still less hazardous than blowing yourself up.