As a recent darkroom worker with only two year's experience, I had been using PMK and ABC pyro for sheet film development. Both of these have known health risks, so I always use gloves to mix or handle them.
Recently, I've switched to Pyrocat-HD and tube development. I wish I had made this change sooner. There is no contact with chemistry at all with this process. The tubes are loaded in the dark and the type I made has screw in tops which are light tight. Pyrocat is very flexible and easy to use, it can be mixed in differing dilutions to go from rapid development to stand development.
Once the tubes are loaded and filled with water, developer of fixer, the lights go back on and the tubes are rolled in a water bath of the correct temperature until completion of the cycle. This method has several advantages over tray development and one or two drawbacks. Development is easy, uniform, simple, consistent and very economical. The tubes were made out of hardware store materials which are available with fittings in many shapes, sizes diameters. Very low tech, but extremely flexible with respect to plus and minus development.
The main drawback I can see is that shuffling a stack of film is not possible and each sheet is done on an individual basis, so a lot of film might take more time. Development by inspection is not done as easily. For me this is offset by not having to worry about any scratches, chemicals on the skin or other problems associated with trays.
To answer your question, I don't know about toxicity. I treat all chemicals as toxic or harmful and try to avoid all skin contact. Try tubes and end your worries.