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large prints from 400 ISO films

The answer was in the first few posts. I have printed up to 24"x36" from 135. Your limits are viewing distance and the optics of the enlarger.

Steve
 
Thank you for putting terminology to it. You definitely have a better vocabulary than I do.

 
I think what you are getting at here is that diffraction is related to the 'relative' aperture which gets smaller as magnification gets bi

No. It was an issue of field flatness at high magnification.

That's why Rodenstock, for instance, made enlarging lenses for specific ranges. Making the jump from 12x to 20x demands a lens specific to that magnification. Switching from an El Nikkor or Focotar to an Apo Rodenstock N solved the problem for me. Much bigger, would have needed the Rodagon G... which, interestingly, was not as good as the N at 20x.
 
I'm sure I'll regret saying this, but many 'serious photographers' would be shocked to see how much better 35mm can be than they ASSUME it can be. It just takes a little effort, or a little desperation.

TMY2, in a true fine grain developer (and I mean the term in the classical sense, of rendering grain cleanly and not mushy) can go to 11x14 and not have visible grain from arm's length away. At a normal viewing distance, a 20x24 can look like it came from 120 neg, not 35mm.

Edwal 12 is a good reference developer. Microdol-X is not. Once you find your way, it is no more difficult than making an 8x10 from Tri-x.