As Diane said, JOBO processing is a bit more practical - less fuss, and also less chance of scratching. The price disadvantage is also true - you should try to get a used unit and tanks together, as a kit - that is typically always the best buy. If you buy (second-hand) tanks later, they will usually cost more when purchased separately. Expert drums are extremely expensive, even used - and all Expert drums won't fit all JOBO processors, so you should check that out before buying (unless you get those in a kit with the processor uniot, which should mean that they can be used on that processor

).
Another possible disadvantage is less control of the development (agitation): once you pour the developer in, the tank rotates all the time - so, you can't vary agitation - and, of course, you can't do stand development
Not all developer/film combos turn out well in JOBO - check out older threads here.
I've just recently used JOBO for the first time with 4x5 (Eflke PL 100 in Rodinal 1+60) - and the results were very nice.
Personally, I'm very happy with it. I've used JOBO previously for 35mm format and medium format, and it makes darkroom work a lot easier, particularly if you do a lot of developing.
And, yes - as Nick said, there's a considerable saving in chemicals used
HTH,
Denis