I have a CPE2 early 2 speed model with lift, which I bought new in the eighties. I have been processing film in it since then, always on the slower speed.
On Monday evening I developed two 4x5" sheets of FP4+ using D76 1+1 at 19.6ºC for 14'45".
I never do a pre-soak with film, never have, never will, for any normal processed film.
When I develop C41 4x5" film, the first developer bath is for 3'15", this is much shorter than what you have mentioned.
You probably don't wish to know just how beautiful my negatives are.
My regime is simple, when first putting in the first solution I run the machine at the high speed, pour the solution in, then by the time 15 seconds has passed, I switch to the slower speed.
I use the fast speed in only to ensure that the film gets covered in developer as fast, and as evenly as possible.
135, 120 and 4x5" sheet film, are all started off the same way, regardless of how long or short my first solution time.
I'm not sure where in the world you are, or how your water supply is, but a pre-soak could be causing you problems. In the late summer months in our water supply lakes, the authorities add a flocculant to the water, this then makes the precipitates in the water drop to the bottom of the reservoir.
I had some streaking problems and the occasional uneven development happenings with colour paper development. I was using a pre-soak to bring the paper and drum up to temperature, dumping then developing.
The Agfa technicians after listening to my complaints and procedure told me to stop doing a pre-soak. I did and the problem went away. Their reasoning was that the precipitate the water authority was using, interfered with the evenness of developing. I believe they were spot on, never had a problem since. They also mentioned that pre-soak for film wasn't recommended as the conditions with either emulsion types was about the same.
When I'm doing large batches of B&W film, I have sometimes upped the temperature to 26ºC and run the developer bath for 5'30". Once again D76, but undiluted, I call it my speedi-brew
One thing I have to ask is this, are you developing 6 sheets at a time or 4 sheets?
I have only once developed 6, 4x5" sheets to a reel, I had uneven development. This was last year when I was testing a couple of lenses.
Mick.