Not something I've tried.
They are optimized for close working distances. But, the focal length is what it is, so presumably it would give you infinity focus when when the nodal point is 50 mm from the film plane. But since there is also no worry about the flange distance in its normal use, it may, or may not be in focus at infinity when fully seated on a Leica body. The ideal body to try something like that on would be a Contax-type since the hellicoid is part of the body, but, I'm not sure the available adaptors give you infinity focus for a 50.