Lots of color shifts can be corrected for in a hybrid process, though. There are, however, interlayer effects (e.g. for boosting color saturation) and DIR effects (read: sharpness), which may depend on correct color developer composition and process conditions. It would be interesting to compare two strips of Vision 3 film side by side - same exposure and subject matter, but ECN-II vs. C-41 development.
Even if all these effects can be controlled and corrected in digital post processing, there is still a non-trivial chance, that Vision 3 stock developed in C-41 is less stable.