The image you sent along looks very much like a series of images by Orloff R. Westmann of Jicarilla Apache people, who he photographed at Taos Pueblo NM, 30 September 1871 (I don't have any bio info on ... See MoreWestmann). The giveaway is the striped blanket pinned up against the plastered adobe wall in the background, and their high-topped moccasins, which are typical.
I don't think you can assume the man on in the left was two-spirited, though the outfit is a bit strange (if warm---it gets cold at Taos!). Men normally just wrapped up in a blanket; men also normally braided their hair, intertwined with ribbon or wrapped with fur which this person has not. Checking out the hands and wrists never seems to work to determine the sex of people---these people lead remarkably difficult lives, and the wear and tear on them was tremendous.
My sense is that this is a pic of two women; a confusing but great shot!