I have often done this kind of thing. Ortho-LITHO films are a sheer pain in the butt for this kind of work. I'd bite the bullet and just buy TMax or FP4 and go the double-sheet way. You can save some money by using fine-grain 4x5 Tmax to generate precision emulsion to emulsion contact inter-positives first, then enlarge those onto 8x10 FP4 final printing negs. Having the right kind of gear is important, including a lens suitable for optimal 2-4 X enlargements from MF and 4x5 to 8x10.
The inter-positive should be slightly overexposed but a tad under-developed, for lower contrast. Then the contrast is boosted developing the final printing interneg itself. So it helps to use films that are not only stiff and dimensionally stable for each step, but with a relatively long straight line characteristic curve. I prefer certain dilutions of HC-110 for this kind of application, but you could hypothetically develop your SECOND sheet of film, the 8x10 printing neg itself, in a staining pyro if you wish. I wouldn't recommend pyro for the prior inter-positive.
With a little practice, this two-sheet method becomes highly predictable, and wastes very little film. With ortho litho, even though it's way cheaper per box, your prolonged treatment expenses in the insane asylum will drastically increase your overall expenditure. Some people seem to like funky-looking prints with horrible development unevenness; not me.
It really helps to have a pin-registered contact printing frame and punch, especially is you need registered secondary masks too. Likewise, doing dye or smudge pencil work on a registered sheet of frosted mylar spares your printing master itself from that kind of treatment, and allows an easy redo of the alterations if necessary.