Light is light, and for the most part the lens doesn't really care all that much as to whether it is projecting onto film, digital sensor, or even just a white sheet of paper.
Optics is a very interesting field in and of itself, and I strongly encourage people to dive into learning more about it, but I'm a geek and very biased.
There are however a few cases where the medium used will have an impact on lens design, but they are generally rather edge case issues rather than hard and fast ones that apply to all lenses for all cameras.
The first and most obvious one is when you're building a camera that will be filtered and only sensitive to a rather narrow band in the light spectrum, such as building an IR camera and lens. If the blue light will never actually have an impact on an image, then we really don't need to care where it goes or how it focuses, and don't have to take nearly as much care with regards to correcting for chromatic aberrations. This allows a slightly simpler design of lens to do just as well in its given narrow-band task, but it will preform very poorly if you then try to employ it to use with wide spectrum film.
Another issue that crops up at times is the angle the light strikes the focal plane at, which can complicate very wide angle designs (Or possibly a lens with exceedingly short flange length?). If it comes from too shallow of an angle then a very narrow beam of light from a given part of the lens becomes more of an oval shape rather than a round circle, which can impact clarity. This issue is amplified in the majority of digital sensor designs due to the micro lens setup on the sensor, and as such lenses need to correct the light path angle or it will lose a lot of light and clarity. Hopefully someone can chip in with more details on modern wide angle lens design, as I seem to be drawing a blank on terminology for the newer designs.
As far as film goes, I really can't think of any negative impact this style of design would actually have, other than increasing the size and weight of the lens assembly, but I would be very interested to hear if someone was aware of other disadvantages of a specific design.