I sort of "semi-jumped" to a conclusion: There are two places where the suspension material may be used: Eye(let)(?)-to-eyelet at the back of the frame, and from the ceiling to wall junction in the gallery, down to the work.
Many "cafeteria" owners avoid ANY "nails into the wall", as eventually, even when filling residual holes with spackle, the wall material will have to be replaced. Such is the case in the Town owned public gallery I curate (note 1). Sheet rock was installed over ca. 1790 interior studs - nothing like 16" on center; or even, or parallel; and we will have a miserable time trying to find anyone who will tackle that particular project again.
Our hanging system consists of perforated metal rods, hanging from a Header at the top of the walls. "S" hooks, etc., connect the work to the rods.
For the eyelet-to-eyelet use in the back of the frame, metal wire, now usually stainless steel, is the way to go ... it is far more resistant to "cutting" and localized wear. It will give as much "warning of failure" as anything else. One incident occurred with stainless wire; it was thin wire at the back of a very heavy Stained Glass Window on display. It broke and there was considerable damage to the piece.
For hanging from a header at the top of the wall, the stretch of nylon is a major problem. It is "bouncy" and there will be a lot of trial and error to get the works to hang at the desired height. Been there, done that - and don't want to do that again. Metal wire will not stretch, but it is noticeable, relatively expensive, and generally difficult to handle. Dacron monofilament has very little stretch, is somewhat expensive, but is probably the most elegant solution.
A couple of comments:
Nylon, as far as I know, is not especially sensitive to UV radiation. It is hydrophyllic (loves water). When it dries it becomes less stretchy - more brittle - and that can lead to failure. I have never encountered ANY sort of problem in tying nylon monofilament together, other than handling the tiny diameters of fine tippets. I googled "ferule crimping" and haven't found one word about anything pertinent to the stuff we might use in picture hanging. Plastic Hose fixtures (see "gardening") are often "crimped" to the hose itself - but I doubt that garden hose has anything to do with this.
"Deep Sea" fishermen often use stainless steel tippets (the forward part of the leader) due to the fact that their quarry, Marlin and the like, have TEETH and tend to bite through nylon.
Note 1. "Curator" - from the Latin - translation: "The guy with the key".