I have had a Lowepro Nova 5 for about 6 years now. Takes a beating and keeps on ticking. It is really configurable on the inside, so much that I can completely re-adapt it for whatever sort of shooting I am doing.
Right now, the inside is set up to hold a Canon A-1 with zoom, several prime lenses, my Yashicamat 124, a mess of Cokin A + P BW filters & holders, three Fidelity 4x5 holders, an additional lens/board for the Graflex, and film.
This still leaves the front pocket with meters and everything, as well as side pockets, top flap for cable releases, and a back pocket for reference literature, grey card, etcetera.
Sometimes I configure the velcro parts inside for two SLR's with a digital, all large format, or all medium format; this still leaves room for the flash, grip, and bounce. The price is right too...