My main issue with modern packs is that there are very few (if any in 2024) panel load packs. A top load keeps things nice and secure, but you're emptying the pack every time you need something unless you are a diligent and methodical packer. The panel loader I own (Gregory Targhee 45) is nice, but the pack bag gets narrower towards the waist. It works ok for a 4x5 outing but fails at 8x10.

