I feel that a lot depends on the individual and how they use the camera.
I've used a few; my fathers Exakta, Minolta SRT-101, Pentax Spotmatic, Maimya/Sekor 1000DTL, Nikkormat FTn, Nikon F and F2, Olympus OM2, and a few others.
Each camera had it's querks, ether in feel or handling.
- The Exakta had a left hand film advance, and a LONG throw. But it has been so long that I forgot the details of the camera. Lenses were full manual, so I had to manually stop down the lens after focusing. A hassle, but I got used to it.
- The Pentax and Mamiya were great cameras, but the threaded lens mount just did NOT work for frequent lens changing, and that KILLED those cameras for me. Whatever theoretical advantage the screw mount had was lost by the hassle of using a screw mount when I had to do frequent lens changes. After the M/S 1000DTL, I went to the Nikkormat and it's bayonet lens mount.
- The Nikkormat FTn shutter speed location was OK, except when quickly changing lenses. It always ended up at 1/1000 sec, because my hand would constantly hit the speed adjustment arm when I changed lens. This was a real irritation for me, as I changed lenses often. But it had a 1/125 sec X-sync. The Copal shutter was the fastest X-sync out there.
- The Nikon lenses all used 52mm filters. For a student, then the usual poor college grad, the common filter size saved me a bunch of $$, in not having to buy duplicate filters for different lenses, that used different filter sizes. Although as a student it took me quite a while to save up to buy the next Nikon lens.
- The Olympus is LIGHT !!! This was not a factor when I was younger, but now I feel each additional pound in the camera bag. So I am really appreciating the lighter Olympus over the heavier Nikon F series.
My hand seemed to get used to most any camera that I used, and I did not feel that any camera is DIFFICULT to use because of layout or design.
In fact my hands are still having a hard time adjusting to the modern DSLR after decades of film camera use. IOW I find the new cameras ergronomically difficult to use, because my hands are used to the controls of the old film cameras.
I did not find the knobs to be a hinderance. In fact one of the things we used was the stop at the end of the knob. Without looking at the camera, we could set the shutter speed; go to 1000, count back (500, 250, 125, 60). We did the same with the aperture ring on the lens, which we had to set manually, with the manual flashes of those days. The control rings on my Nikon DSLR do not have end stops, and I have to LOOK at the display to set the camera. I can't set the controls blind like I can with my film cameras. So in some cases, it is actually slower for me use than my old film cameras.
A motor winder was a HUGE plus for the later cameras. I did not need the 4fps of a motor drive, but the ability to quickly advance to the next frame without moving my right hand and thumb would have been heaven. As it was, I learned to crank that film advance lever pretty fast.