We've two cats at that weight, but they were born behind our TV, so we were able to raise them to be civil. They sometimes grab lightly with their mouths, but I don't think they know biting is even an option. I've 5 cats, my best friend has 1, and her father has 1. Every two weeks we rank how well they were for nail trims - we don't have much else going on in life, lol.
I started clipping nails biweekly when they were about 6 months old. I didn't start brushing their teeth until they were a month shy of their 2nd birthday. If I started earlier it would be easier.
Their mother was a stray (not feral) and is tiny, less than 7#. We can't clip her nails easily, and being so small, they are like hypodermics - plus she's not good at retracting them. If she merely pushes with her paw, she sticks to my hand. I have to block her front paws when brushing teeth.
Then there is my best friend's father's cat Lance, whom I dubbed Mr. Bitey; over 14#. He was mean when they got him, but they did good work and he's rarely nasty anymore. Unfortunately, he considers biting a valid form of social interaction. I taught him to not use his nails, and to play-bite, which can still hurt with tiny teeth. However, when he gets enthusiastic he forgets himself... and he can now tell if my exclamation of "ouch" is fake. I'm getting him used to occasional mundane interactions, like being held & petted. He'd still rather play bite-the-hand (we once had a mid-sized Doberman mix that also liked that game).
To do Mr Bitey's nails, I hold him and let him "playfully" gnaw on my hand while my friend does the trimming. We've not attempted to brush his teeth.
TMI: London Broil toothpaste doesn't taste like meat.