Classic low-density area caused by bubbles clinging to the film at the top of the tank or not quite enough developer in the tank to cover the film.
Check to make sure that the amount of developer you are using covers the film reel completely and that your reel isn't inching upward during the development (some systems have this latter problem).
Then, when developing, make sure to rap the tank on the countertop after each agitation cycle to dislodge the bubbles that may form.
Also, be sure to clean the tank and reel well after developing, especially if you use wetting agent like Photo Flo in the tank. If you have plastic reels especially, Photo Flo can leave a residue that causes foaming and inhibits development.
That should clear up your problems.
Doremus