Rob,
Check focus spread with the aperture wide open. Then determine the optimum taking aperture based on the focus spread. I use the method described here:
http://www.largeformatphotography.info/fstop.html and focus as described here:
http://www.largeformatphotography.info/how-to-focus.html.
However, the OP was just looking to find out if tilt might help. If tilting results in a smaller focus spread (wide open), then it has helped, if not, then it hasn't; that's all there is to it.
Deciding what aperture to take at is a different issue entirely. Many stop down and check their focus points, some "stop down till everything is sharp and then stop down one more stop," etc. I don't even bother to check the ground glass after finding my focus spread and setting my focus halfway between. I simply consult the chart I've made for the optimum f-stop for focus spread and stop down to that. There isn't a "wide margin of error" at all; it is very precise. I rarely (very, very rarely) miss the DoF I'm shooting for, and then only in extreme cases (e.g., foreground 6 inches from the camera and a scene to infinity).
Back to the original topic for one more comment: studying what movements do with an eye to how they move the plane of sharp focus around in front of the camera (and not just what happens on the ground glass) is extremely helpful in determining how to apply movements in the field. I usually picture where the plane of focus should be placed in a scene to get optimum DoF before I set up the camera. By then, I have a good idea of what movement(s) need to be applied. Trickiest, of course, are scenes with lots of near/far and lots of close verticals that extend up into the top half of the scene and close objects with distant ones behind them. Sometimes simply stopping down a lot is the best solution, but often, the focus-spread test shows that a skosh of tilt and/or swing helps, and allows one to use a larger (more optimum) aperture.
Best,
Doremus