I use Kodak chemistry for both E-6 and C-41, replenished. It's very economical. Using Kodak E-6 fixer for both atm.
C-41 is more convenient/simpler to process, as it has much less steps and short times.
That said, E-6 is not hard, just more time consuming, to sit there, do the 6 minute dev step, then the 2 minute water soak, then the 1 minute reversal bath, then the colour developer step where you can finally walk away.
Versus C-41, where it's just 3m 15s developer step, bleach and walk away, or stop, then bleach and walk away. Come back and agitate it now and then, then finish the rest of it etc.
E-6 is the simplest for replenishment, you dont have a bunch of different rates for different films.