I'd think there would be a fair amount of qualitative loss, fine detail wise, using those things. Strong ND filters have caught on because lots of digital cameras do not have a low ASA option, and need to be slowed down for certain kinds of shots, like flowing water or blurred ocean waves.
In landscape work, gradational ND's became a fad for trying to control overexposure of the sky relative to the foreground, especially with color chrome films. Galen Rowell popularized them, and the Sing-Ray series even used his name for marketing theirs. But every single one of his own shots I've ever seen that relied that looked like it - distinctly fake tonality and color, and overall, kitchy, touristy. Sometimes a reflection in a foreground stream or pond was even more intensely colored that the sunset sky about it - a dead giveaway. I've never used these, and never will. But if someone were really careful with them, well, maybe... I just find it a detour or clumsy trick in lieu of really understanding specific films and lighting situations.