Vuescan -- a worthwhile addition. You can change parameters for your raw scans, review the results, and save without having to rescan, so no time wasted. EpsonScan is functional but I almost always use Vuescan.
profiling -- Vuescan supports profiling using an IT8 target. Not strictly required, but if you scan a lot
of color this may be helpful. You will need reflective and/or film IT8 targets.
T locks -- I have them but never use them -- I use ANR glass and get scans that are sharp edge-to-edge. Most of my film is now scanned in a Nikon 9000; I couldn't get sharp scans until I started using glass carriers for that scanner, too.