There are trade offs of any normal lens design. Other than the Swiss Kern 50 1.7 and the knock off Chinon 50 1.7 in M42 mount macro, Macros are a stop slower, boka will be different, and depending on the age of lens and coating there can be different resulting contrast and color rendering. I typically use a normal mid range 1.9 to 1.4, which is the fast lens I have in 35mm. I use a 50 2.8 Sigma in Minolta Mount of 5 pin Minolta 100 A mount if I am shooting at the local Botanical Garden as I carry a tripod. If my intent to shoot all macro I use a bellows or a set of extension tubes and either a 100 or 50mm lens, sometimes a short zoom.