Do folks shoot 4X5 substantially differently
Yes. No. Maybe. Sometimes I shoot 6x6 from a tripod and then it isn't all that different in terms of materials choice from 4x5. Either way, I agree with
@jim10219 above in that film speed tends to matter a little less with 4x5 than it does with smaller (or rather, handheld) formats. That is to say - with 4x5, you'll find yourself stopping down quite a bit to get decent depth of field. That means you need a lot of light, and even more so if you're doing close-ups (that bellows correction stuff adds up pretty fast). If you're a poor sod like me and the only lighting you have is a couple of flimsy consumer grade strobes, then a somewhat faster film is sometimes a necessity with the strobes maxed out and nowhere left to go but up into the higher ISOs.
So what film to choose? You're on your own there. Different strokes for different folks and all that. I personally shoot a lot of Foma 100 in 4x5. Sometimes some TMAX100. Sometimes some Foma 400. Sometimes Ektascan B/RA xray film cut down to 4x5. Those would cover probably 95% of my 4x5 negatives.
Why Foma 100? Because it's cheap and cheerful. It just works. Its relatively large grain (for a 100 film) isn't really a problem in 4x5. I like it for just about anything. It works a charm with alternative printing processes as well.
Why Foma 400? Same as 100, just a little faster in the odd situation when that matters. And it gives pretty nice tonality with human skin, I find.
Why TMAX100? Because unlike the Foma films, it has decent/good reciprocity behavior, and it's more linear. I use it whenever Foma just won't cut it. But I don't like its gloss on both sides or the fact that it blocks several stops of UV (forget about salt prints from TMX negatives).
Why xray film? Because we're all crazy sometimes. It's nice stuff to mess around with on a rainy day with little inspiration and just the desire to get some film wet.
So why would you use Delta 100, FP4+, TMY-2, or whathaveyou? For whatever reason it works for you of course! If you like FP4+ in smaller formats, you'll probably like it in 4x5 as well. There's very little not to like about FP4+ after all. And in the end, the same goes for many, if not most, films out there.