Always try it without sizing first. Even if you're sure you're going to need to size the paper, it helps to get a baseline to know how much. After you've figured out how much size you need, then work on the best way to apply it. Some methods are great for heavily sizing paper and some methods are better for lightly sizing paper. The paper, the size, the emulsion, the tools you have available... it'll all play an effect on what works best for you.
Your best bet is to keep it simple, and not add any unnecessary steps. You'll be better off if you try to limit yourself to addressing actual problems that you've experienced, rather than trying to address problems that you may theoretically experience with stuff like this. For most of the papers I've worked with, sizing is only necessary when doing multiple exposures and washes.