When you start to see a lot of little black bits (silver selenide), your Se solution is starting to go. When you accumulate a lot of this precipitate, you should notice that it is taking longer for you prints to tone. This is the time to throw it out. In many soils, particulary in the arid SW US, Se is encountered relatively in high levels. When these levels get too high, it will effect plants. I think dispersing it in the soil is the best way. Typically, I find that a 1/2-gallon of working 1:20 solution will do about 40 or more 8x10 prints before it gets to this stage.