I have noticed no significant difference, even between different drum sizes either full or lightly loaded. At least my Jobo (ATL-1500) does a good enough job with temp regulation and agitation consistency so that there is remarkable consistency.
I think the key is, as you said, making sure you have enough developing agent, regardless of working-strength dilution, for the film surface area you are processing. This means, for instance, that every 8x10 equivalent needs about 100mL of Xtol stock, or 200-250mL D76 stock, or ~6mL HC-110 syrup.
8x10 equivalent being a roll of 135-36, 120, or 4-4x5.